HONY D001 Antioxidant Edition: Scientific Anti-Aging, Rebuild Skin's Defense

What is Oxidation?

Oxidation is the process where substances combine with oxygen—like sliced apples turning brown or iron rusting. In the human body, this manifests as free radical attacks on cells.

• Damaged collagen → Wrinkle formation

• Impaired cell membranes → Reduced moisture retention

• DNA damage → Accelerated aging

UV rays, stress, pollution, and more exacerbate oxidation. Antioxidation neutralizes excess free radicals, helping skin defend against aging.

Signs of Skin Aging

❶ Dryness & roughness: Diminished moisture retention, poor makeup adherence

❷ Fine lines emergence: Fine lines quietly appear around the eyes and lips

❸ Sagging & drooping: Blurred contours, loss of a sharp jawline

❹ Dullness & lackluster: Uneven skin tone, loss of healthy radiance

Antioxidation – Free Radicals

Two Major Sources of Free Radicals

Endogenous Sources

• Cellular energy production: Naturally generated by mitochondria during energy synthesis

• Inflammatory responses: Released by the immune system when fighting infections

• Metabolism: Byproducts of normal physiological processes

Extrinsic Sources

• UV radiation: Sunlight exposure triggers massive free radical production in the skin

• Air pollution: Environmental toxins like PM2.5 and automobile exhaust

• Unhealthy lifestyle: Factors including smoking, excessive alcohol consumption, sleeplessness, and stress

• Chemical substances: Substances such as pesticide residues and certain pharmaceutical ingredients

As we age, the body's antioxidant defense system declines in function. Coupled with the persistent exacerbation of extrinsic factors, this leads to the accumulation of oxidative damage, accelerating the aging process.

How to Fight Oxidation?

Free radicals are the primary culprit behind skin oxidation—effectively eliminating them is key to delaying aging. Below are three scientific pathways to neutralize free radicals:

1. Direct Neutralization

   Donate electrons via antioxidant ingredients to directly stabilize free radicals:

   • Vitamin C: Water-soluble free radical scavenger

   • Vitamin E: Protects cell membrane lipids from attacks

2. Activate Endogenous Defense

   Boost the skin’s intrinsic antioxidant system:

   • Enhance cells' self-repair capacity

   • Establish a long-term protective mechanism

3. Repair Damaged Cells

   While scavenging free radicals:

   • Repair oxidized proteins

   • Stimulate collagen synthesis

   • Restore skin barrier function

High-Efficiency Antioxidation = Effective Free Radical Elimination + Endogenous Defense Enhancement + Timely Damage Repair

Efficacy Test

Test 1: Riclin (Hony D001) – High Antioxidant Activity, a Viable Antioxidant Replacement

The results show that Riclin (Hony D001) exhibits excellent in vitro antioxidant properties, with free radical scavenging activity in a concentration-dependent manner.

Test 2: Riclin (Hony D001) – Primarily Protects Immune Cells from Aging

In the cell aging model induced by D-gal (D-galactose), the RAW.7 immune cell line is the most sensitive.

Riclin (Hony D001) (+ 2 μg/mL, ++ 40 μg/mL) effectively protects immune cells from aging.

Riclin (Hony D001) effectively protects RAW264.7 immune cells against D-galactose-induced apoptosis.

A: Control; B: D-galactose (400 mM); C: D-galactose (400 mM) + Riclin (Hony D001) (20 μg/mL); D: D-galactose (400 mM) + Riclin (Hony D001) (40 μg/mL)

Test 3: Riclin (Hony D001) – Effectively Prevents Skin Aging

Riclin (Hony D001) treatment increased skin thickness, skin collagen fiber content, and hydroxyproline levels in aged mice.

Efficacy Performance

• 8 female volunteers aged 18–60 years;

• Application of 0.5% Hony D001 glycan solution (sample group) or placebo (control group) to periorbital skin;

• Once daily for eight consecutive weeks;

• Observation of periorbital wrinkle changes after eight weeks.

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